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KMID : 0366220150500020073
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Korean Journal of Hematology
2015 Volume.50 No. 2 p.73 ~ p.79
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Apoptosis: role in myeloid cell development
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Sarvothaman Shilpa
Undi Ram Babu
Pasupuleti Satya Ratan
Gutti Usha
Gutti Ravi Kumar
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Abstract
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Hematopoiesis is the process that generates blood cells in an organism from the pluri-potent stem cells. Hematopoietic stem cells are characterized by their ability to undergo self-renewal and differentiation. The self-renewing ability ensures that these pluripotent cells are not depleted from the bone marrow niche. A proper balance between cell death and cell survival is necessary to maintain a homeostatic condition, hence, apoptosis, or programmed cell death, is an essential step in hematopoiesis. Recent studies, however, have introduced a new aspect to this process, citing the significance of the apoptosis medi-ator, caspase, in cell development and differentiation. Extensive research has been carried out to study the possible role of caspases and other apoptosis related factors in the devel-opmental processes. This review focuses on the various apoptotic factors involved in the development and differentiation of myeloid lineage cells: erythrocytes, megakaryocytes, and macrophages.
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KEYWORD
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Apoptosis, Caspase, Megakaryocyte, Erythrocyte, Monocyte, Differentiation
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